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Moyamoya disease may occur at any age, though symptoms most commonly occur between 5 and 10 years of age in children and between 30 and 50 years of age in adults. The first symptom of moyamoya disease is usually stroke or recurrent transient ischemic attacks (TIAs), especially in children. Adults may also experience these symptoms but more often experience bleeding in the brain (hemorrhagic .
CHAPTER 356 Adult Moyamoya Disease. Since its initial discovery some 50 years ago, the clinical features of the disease have become clearer. It has been hypothesized that in the setting of arterial stenosis-occlusion, hypoxic regions of the brain induce deep collateral flow by the dilation of tortuous perforating arteries.
Adult-onset moyamoya disease has been shown to have distinct clinical characteristics that set this condition apart from that seen in the pediatric population. Adults are less likely to present with cerebral ischemia and much more likely to present with cerebral hemorrhage.Cited by: 94.