Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to androgens and estrogens.Other steroid hormones such as progesterone, cortisol, and other corticosteroids are bound by transcortin.SHBG is found in all vertebrates apart from birds.Aliases: SHBG, ABP, SBP, TEBG, sex hormone binding .
SHBG test measures the levels of SHBG in your blood and is most often used to help evaluate for testosterone deficiency or excess. The sex hormone binding globulin (SHBG) test may be used to help evaluate men for low testosterone and women for excess testosterone production.
Sex hormone binding globulin (SHBG) is a protein produced by the liver that transports the hormones testosterone (an androgen), dihydrotestosterone (DHT) (an androgen), and estradiol (an estrogen) in the blood as biologically inactive forms.Changes in SHBG levels can affect the amount of hormone that is available to be used by the body's tissues.
SHBG: Sex hormone-binding globulin (SHBG), a homodimeric 90,000 to 100,000 molecular weight glycoprotein, is synthesized in the liver. Metabolic clearance of SHBG is biphasic, with a fast initial distribution from vascular compartment into extracellular space (half-life of a few hours), followed by a slower degradation phase (half-life of several days).